If you have arthritis in any form, then you know the intense joint pain associated with the condition. During these times it feels like the only thing that can relieve our pain are powerful prescription drugs. But, you might be surprised to learn the healing power of arthritis cream.
Many over the counter medications today actually feature incredibly powerful active lab ingredients, or natural joint pain relievers like hemp. But how do you know which product is the definitive best arthritis cream? Luckily, in this article, we review and rank some of the most effective outcomes. Check them out!
However, before we get to the best arthritis cream, we will first go over some frequently asked questions. These questions remain essential because determining which product will be most effective for you requires knowledge of both the general condition and your specific case.
Comparison of Table
PRODUCT | DETAILS |
---|---|
![]() Penetrex Pain Relief Therapy — Two Ounces | Ingredients: The top active ingredients include arnica, choline, glucosamine, MSM (DMSO2), boswellia serrata, cetyl myristoleate, and vitamin B6 Odor: Neutral, faint odor Quantity: Two ounces |
![]() Biofreeze Pain Relief Gel — Four Ounces | Ingredients: Menthol Odor: Minty and cool Quantity: Four ounces |
![]() Activene Arnica Gel-Cream — Three Ounces | Ingredients: Menthol (3.7%), Aloe Barbadensis Leaf Extract, Carbomer, Arnica Montana Flower Extract, Dimethyl Sulfone (MSM), EDTA, FDC Blue #1, Ilex Paraguarenis Leaf Extract, Melaleuca Alternifolia (Tea Tree) Oil Extract Odor: Minty and chemical-like Quantity: Three ounces |
![]() Hemp PainRelief Cream — Two Ounces | Ingredients: Water, Aloe Vera, Esters of Caprylic and Capric Acids, Trideceth-6, Emu Oil, Hemp Oil, Arnica Montana Flower Extract, MSM, Boswellia Serrata, Glucosamine, Menthol, Phenoxyethanol, Potassium Sorbate, Citric Acid Odor: Herbal and minty Quantity: Two ounces |
![]() Aspercreme Pain Relieving Creme With Lidocaine — Five Ounces | Ingredients: Lidocaine Odor: No odor Quantity: Five ounces |
Arthritis Frequently Asked Questions
Here are some of the most popular questions asked by people who either believe or just found out that they have arthritis.
What Does Arthritis Feel Like When You Have It?
What Are the Different Types of Arthritis?
What Are Some Ways You Can Deal With Arthritis?
How We Reviewed the Cream Options On This List

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We review the arthritis creams on this list by looking at some of the most popular over-the-counter medications available on the market right now. We then critique three critical areas that help us give an accurate ranking for the product. Specifically, we look at ingredients, effectiveness and the overall price.
We also look at user reviews, so you know which products help specific arthritis, and which ones sometimes come with side effects. Once we come to a consensus, we then rank the products from best to worst.
Overall Price Range for Arthritis Cream
The price of arthritis-relieving cream depends both on the brand you use and the quantity included in the size you order.
Top Five Best Cream Options for Relieving Arthritis Pain
1) Penetrex Pain Relief Therapy — Two Ounces
- Apply Penetrex to your Back, Neck, Knee, Hand, Foot, and more. Penetrex is recommended for use on its own and is also...
- Utilizing a revolutionary delivery system, Penetrex delivers clinically evaluated ingredients including Arnica,...
- Your Penetrex purchase is backed by our happiness support. Try our products without worry because we’re confident that...

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- key features
- pros & cons
One of the biggest pros associated with this product would probably be the overwhelming amount of positive reviews associated with it. Many people report that the cream does successfully get rid of pain after exercise or before a flare-up. Plus the price represents an excellent mid range.
Unfortunately, the massive amounts of positive reviews do not automatically mean it will work for everyone. Some cases of tendonitis did not receive relief when using the product. Penetrex also does not use natural ingredients which might be a deal breaker for some people.
2) Biofreeze Pain Relief Gel — Four Ounces
- #1 Clinically Recommended: Trusted by pharmacists, physical therapists, chiropractors, massage therapists, podiatrists,...
- Unique cooling menthol formula is backed by science and research-proven to deliver fast acting, long lasting and deep...
- Trusted by some of the world's best athletes and athletic trainers

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- key features
- pros & cons
Many people note that Biofreeze Pain Relief Gel helps reduce pain for a reasonable amount of time. The cooling sensation helps with hot flashes that occur with arthritis. It is also a colorless gel that dries quickly on your skin, so you do not need to worry about it staining you at all.
Unfortunately, there are some cons associated with the product. For example, some people might not like the cooling sensation associated with the product. Other loyal customers note that the company recently changed the product formula to the point that you need to apply lots of the gel to feel anything.
3) Activene Arnica Gel-Cream — Three Ounces
- THOUSANDS OF HAPPY CUSTOMERS – from professional physiotherapists to arthritis sufferers. We have a track record of...
- MADE IN THE USA with the highest quality standards and registered with the FDA. Cruelty free! Ingredients include Arnica...
- NON-GREASY, NON-STAINING, FAST ABSORBING Arnica gel cream with a refreshing mint scent. Within minutes, the cream is...

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- key features
- pros & cons
If you experience intense pain from your arthritis, then we do not think you can go wrong with this product. It is one of the most effective ones on this list in terms of blocking out pain. That is probably why so many chiropractors use it.
However, keep in mind that some people reported that the product did not work for them. While most people seemed to experience at least some pain relief, a few outliers got nothing. So, the product is not a cure-all product.
4) Hemp PainRelief Cream — Two Ounces
No products found.

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- key features
- pros & cons
The natural component of the product is the main selling point. If you find that the harshness of some of the other product leaves you with a rash or similar skin condition, then the Hemp PainRelief Cream is a good alternative. It is also great at blocking pain.
The biggest con associated with this hemp cream comes in the form of its price tag. Because of the natural active ingredients, the brand uses a small amount of it actually costs quite a bit of money.
5) Aspercreme Pain Relieving Creme With Lidocaine — Five Ounces
- INCLUDES: One (1) 4.7-ounce bottle of Aspercreme with Lidocaine Maximum Strength Pain Relief Cream
- RELIEVES PAIN AT THE SOURCE: Topical numbing cream with 4% lidocaine targets more pain receptors* to numb away minor...
- WORKS IN MINUTES: Fast-acting Lidocaine cream penetrates muscles and joints to provide numbing relief for hours

image via: amazon.com
- key features
- pros & cons
The biggest pro associated with this brand would be its affordable price. You will not find a better deal in terms price per ounce ration. This reason is that the active ingredient in the product, the lidocaine, works exceptionally well with nerve damage.
Unfortunately, there is still only a small percentage of lidocaine in the product. As such, many people seemed to report that the product did not provide them with much pain relief. However, this issue is understandable considering the low price of the object. So, you do not risk much when you use it.
The Verdict
In our opinion, the Penetrex brand offers the most effective relief for people suffering from most types of arthritis pains. If you want a right starting place for trying out which medications work for you, then we recommend this brand. However, as we mentioned, the product does not work correctly for everyone.
Some others might not like the fact that it does not come with natural ingredients. If these issues arise, then we recommend trying one of the other products. In particular, the Hemp brand offers a great alternative if you do not mind paying a little extra for the natural ingredients. We hope this article helped you find the best arthritis cream for your specific pain needs. Good luck in the future!
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Last update on 2021-02-28 / Affiliate links / Images from Amazon Product Advertising API